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An error message indicating “iTunes has detected a problem with your audio configuration” is probably caused by an error in iTunes or its QuickTime software. If uninstalling and reinstalling these applications does not work, you can focus your attention on the audio settings for Windows as a whole.
Here are some fixes that have helped other users iTunes has detected a problem with your audio configuration Audio/video playback may not work properly Error. You may not have to try them all; just browse the list until you find the one that suits you.
Windows Sound Troubleshooting
If the error message still appears after reinstalling iTunes and QuickTime, a more common problem with the sound on your system may be to trigger it; test the sound in another program to see if it does. Download and install the latest drivers for your sound card and motherboard from the manufacturer’s website. These drivers include the latest patches and fixes from the developer and should ensure that your hardware can work seamlessly with iTunes. Microsoft offers an audio troubleshooting tool (link in resources) that can be downloaded free of charge from the support website that may be able to identify and resolve the cause of your problem. If you view the status of your sound card by right-clicking on the entry in the Device Manager and selecting Properties, you can detect hardware problems.
Reinstalling QuickTime
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If QuickTime is installed on your computer, it may conflict with iTunes and iTunes has detected a problem with your audio configuration. Audio/video playback may not work properly. This will allow you to reinstall QuickTime to see if the problem is solved. To do this, simply remove QuickTime from your PC, then go to the official Apple website to download and install the latest QuickTime file.
To remove QuickTime from your PC:
1) On your keyboard, press the Windows logo key, type Quicktime, and once QuickTime Player appears, right-click and click Uninstall.
2) In the Programs and Features window, right-click QuickTime and click Uninstall.
3) Follow the on-screen instructions to uninstall QuickTime.
Here’s how to install the latest version of QuickTime:
1) Go to Apple Support for Windows QuickTime and click Download.
2) Double-click on the downloaded file and follow the wizard to install QuickTime.
Connecting an audio device
The first thing we will try is to connect an audio device to your computer. It seems that iTunes has an error where if you don’t have an audio device connected, the application reports an error and refuses to load the media.
This seems odd, because even if no audio device is available, the application should only transmit sound to the drivers, who should do everything from there. Nevertheless, try to connect a headset/audio to your computer and make sure it is recognized. Then try restarting the application and check that the problem is solved.
CONCLUSION
You must also make sure that iTunes on your computer is updated with the latest version. Normally, Apple runs a service called the Apple Update Service on Windows. You should run it and see if there are any updates. If not, go to the official iTunes website and install the latest version manually.
https://discussions.apple.com/thread/8460743
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