Repair Sysprep Fatal Error, Could not load MSESysprep.dll

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Several errors can occur when executing the system setup tool. One of these errors is the fatal Sysprep error, Unable to load MSESysprep.dll

This error is common in an older version of Windows and occurs due to the absence of a .dll file in the installation directory.

If you are also affected by this error, here are some troubleshooting tips to help you fix the fatal Sysprep error, Unable to load the MSESysprep.dll error in Windows.

Reinstalling Microsoft Essential Security

Since the missing DLL is due to Microsoft Security Essential, if you don’t want it to be part of the master image, you can reinstall it and then uninstall it, making sure that all parts of the package have been properly removed.

Delete the Panther folder from Sysprep.

  • Open Windows Explorer and navigate to the C:\Windows\System32\sysprep\ folder.
  • Delete (or rename) the Panther folder.
  • Now restart sysprep. Sysprep should run successfully and without problems.

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Removing an invalid registry entry

  • Press the Windows + R key to open Run.
  • Type regedit and click OK to open the Registry Editor.
  • In the Registry Editor, click File and Export. Give the file a name and save it in a safe place. This allows you to restore the registry files if something goes wrong.
  • In the Registry Editor, navigate to the following location :
  • HKLMMicrosoftWindowsCurrentVersionSetupSysprepCleanup Software
  • Right-click on the cleaning key.
  • Choose Permissions.
  • In the Permissions window, choose Administrators.
  • Under Permissions for Administrators, select the Allow full control check box.
  • Click Apply and OK to save the changes.
  • Select the cleanup key again.
  • In the right pane, remove the following value :
  • 2D153B43-11B4-461F-AA43-832B2C8B8872
  • Right-click the value and choose Delete.
  • Close the registry editor.


The Fatal Sysprep, Unable to load MSESysprep.dll error seems to occur due to incomplete uninstallation of Microsoft’s security essentials. If you follow the steps in this article, you can correct the error and continue the Sysprep process.

If you have any additional questions or suggestions, feel free to leave them in the “Comments” section below.

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